Preheat Air Fryer: Preheat your air fryer to 400°F (200°C).
Prepare Breading Station: In three separate bowls, place the flour in one, beaten eggs in another, and mix breadcrumbs, garlic powder, onion powder, smoked paprika, salt, and black pepper in the third.
Coat Chicken Tenders: Dip each chicken tender first into the flour, shaking off excess, then into the beaten eggs, and finally into the breadcrumb mixture, pressing the breadcrumbs onto the chicken to adhere.
Air Fry the Chicken Tenders: Spray the air fryer basket with cooking spray. Place the breaded chicken tenders in a single layer in the basket, ensuring they are not touching. Spray the tops of the tenders with cooking spray.
Cook in Batches: Depending on the size of your air fryer, cook the tenders in batches to avoid overcrowding. Cook for 10-12 minutes, flipping halfway through, or until the tenders are golden brown and have an internal temperature of 165°F (74°C).
Make Honey Mustard Sauce: While the chicken is cooking, whisk together mayonnaise, Dijon mustard, honey, lemon juice, salt, and pepper in a bowl. Adjust the seasoning to your liking.
Rest and Serve: Once cooked, let the chicken tenders rest for 5 minutes. Serve the crispy tenders with the honey mustard sauce on the side.